PEGylated pharmaceuticals on the market
PEGylated pharmaceuticals on the market
The clinical value of PEGylation is now well established. ADAGEN (PEG- bovine adenosine deaminase) manufactured by Enzon Pharmaceuticals, Inc., US was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) in March 1990, to enter the market. It is used to treat X-linked severe combined immunogenicity syndrome, as an alternative to bone marrow transplantation and enzyme replacement by gene therapy. Since the introduction of ADAGEN, a large number of PEGylated protein and peptide pharmaceuticals have followed and many others are under clinical trial or under development stages. Some of the successful examples are:
* PEGASYS: PEGylated interferon alpha for use in the treatment of chronic hepatitis C and hepatitis B (Hoffman-La Roche)
* Pegintron: PEGylated interferon alpha for use in the treatment of chronic hepatitis C and hepatitis B (Schering-Plough / Enzon)
* Oncaspar: PEGylated L-asparaginase for the treatment of acute lymphoblastic leukemia in patients who are hypersensitive to the native unmodified form of L-asparaginase (Enzon). This drug was recently approved for front line use.
* Neulasta: PEGylated recombinant methionyl human granulocyte colony-stimulating factor for severe cancer chemotherapy induced neutropenia (Amgen)
* Doxil/Caelyx: PEGylated liposome containing doxorubicin for the treatment of cancer (Ortho Biotech / Schering-Plough)
Monday, February 22, 2010
Friday, February 19, 2010
DNA Sequencing Service
DNA Sequencing Service
DNA Sequencing Service
The determination of exact DNA sequence is both an art and a science requiring a heavy investment in technology, expertise and training. Geneservice has made that investment and can meet all your sequencing needs. We have completed large genomic sequencing projects on the mouse and pufferfish genomes, however we are happy to provide our expertise for orders of any size.
DNA Sequencing Service
The determination of exact DNA sequence is both an art and a science requiring a heavy investment in technology, expertise and training. Geneservice has made that investment and can meet all your sequencing needs. We have completed large genomic sequencing projects on the mouse and pufferfish genomes, however we are happy to provide our expertise for orders of any size.
Friday, February 12, 2010
SynergyLaserHairRemoval
SynergyLaserHairRemoval
What is IPL Laser Hair Removal?
IPL Laser Hair Removal is the permenent removal of unwanted or unnecessary hair on any part of the body using a safe and effective laser over a course of treatments.
Laser Hair Removal is the easiest and most convenient solution to permanently remove hair from anywhere on the body.
How much does Laser Hair Removal Cost?
The cost varies from person to person depending on factors such as hair colour, density, skin tone and area size.
We offer a FREE consultation for anyone who would like to come and talk to a Laser Specialist to find out more about the procedure, what you can expect and the different pricing options for courses etc.
We recognise the super benefits of this to our clients and so refund the initial consultation fee of £25 if you agree to go ahead with the Laser Hair Removal.
Our laser specialist is highly trained and will be happy to answer any questions you may have. The usual methods of removing your unwanted hair are a real chore. Shaving, waxing or using tweezers takes up precious time and can be very uncomfortable.
At Synergy Spa we use the very latest Intense Pulsed Light (IPL) technology to provide fast, non-invasive hair removal for most skin types and hair colours. The Chromolite-ep (extended pulse) IPL machine can treat most areas of the body in both women and men, including the face. It treats a much larger area of skin per light pulse than laser hair treatment, which means treatment can be faster and cheaper. In the vast majority of cases a series of treatments will permanently reduce the unwanted hair from the target area.
What is IPL Laser Hair Removal?
IPL Laser Hair Removal is the permenent removal of unwanted or unnecessary hair on any part of the body using a safe and effective laser over a course of treatments.
Laser Hair Removal is the easiest and most convenient solution to permanently remove hair from anywhere on the body.
How much does Laser Hair Removal Cost?
The cost varies from person to person depending on factors such as hair colour, density, skin tone and area size.
We offer a FREE consultation for anyone who would like to come and talk to a Laser Specialist to find out more about the procedure, what you can expect and the different pricing options for courses etc.
We recognise the super benefits of this to our clients and so refund the initial consultation fee of £25 if you agree to go ahead with the Laser Hair Removal.
Our laser specialist is highly trained and will be happy to answer any questions you may have. The usual methods of removing your unwanted hair are a real chore. Shaving, waxing or using tweezers takes up precious time and can be very uncomfortable.
At Synergy Spa we use the very latest Intense Pulsed Light (IPL) technology to provide fast, non-invasive hair removal for most skin types and hair colours. The Chromolite-ep (extended pulse) IPL machine can treat most areas of the body in both women and men, including the face. It treats a much larger area of skin per light pulse than laser hair treatment, which means treatment can be faster and cheaper. In the vast majority of cases a series of treatments will permanently reduce the unwanted hair from the target area.
Tuesday, February 2, 2010
About Phendimetrazine
About Phendimetrazine
Phendimetrazine is a sympathomimetic amine and is similar to an amphetamine. It is known as an "anorectic" or "anorexigenic" drug. Phendimetrazine works by stimulating the central nervous system, which increases your heart rate and blood pressure and decreases your appetite.
Types of Phendimetrazine
# ADIPEX-P tablets
# Ionaminionamin
# Duromineduromine
# Genericgeneric phentermine
Phendimetrazine is a sympathomimetic amine and is similar to an amphetamine. It is known as an "anorectic" or "anorexigenic" drug. Phendimetrazine works by stimulating the central nervous system, which increases your heart rate and blood pressure and decreases your appetite.
Types of Phendimetrazine
# ADIPEX-P tablets
# Ionaminionamin
# Duromineduromine
# Genericgeneric phentermine
ABOUT Mesothelioma
Mesothelioma
ABOUT
Mesothelioma
Mesothelioma, asbestosis and other asbestos claims......
Getting proper compensation for victims from UK employers...... Long track record of success for UK & worldwide clients......
Mesothelioma compensation: asbestos exposure legal claims, for mesothelioma and asbestosis conditions, by independent specialist solicitors team with a very long track record of success getting clients proper compensation.
Mesothelioma, more precisely malignant mesothelioma, is a rare form of cancer that develops from the protective lining that covers many of the body's internal organs, the mesothelium. It is usually caused by exposure to asbestos.[1]
Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart,[2] the pericardium (a sac that surrounds the heart) or tunica vaginalis.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. It has also been suggested that washing the clothes of a family member who worked with asbestos can put a person at risk for developing mesothelioma.[3] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases the risk of other asbestos-induced cancers.[4] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
ABOUT
Mesothelioma
Mesothelioma, asbestosis and other asbestos claims......
Getting proper compensation for victims from UK employers...... Long track record of success for UK & worldwide clients......
Mesothelioma compensation: asbestos exposure legal claims, for mesothelioma and asbestosis conditions, by independent specialist solicitors team with a very long track record of success getting clients proper compensation.
Mesothelioma, more precisely malignant mesothelioma, is a rare form of cancer that develops from the protective lining that covers many of the body's internal organs, the mesothelium. It is usually caused by exposure to asbestos.[1]
Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart,[2] the pericardium (a sac that surrounds the heart) or tunica vaginalis.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. It has also been suggested that washing the clothes of a family member who worked with asbestos can put a person at risk for developing mesothelioma.[3] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases the risk of other asbestos-induced cancers.[4] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).
The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.
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